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In patients with heart failure, the beneficial effects of fosinopril sodium are thought to result primarily from suppression of the renin-angiotensin-aldosterone system inhibition of the angiotensin-converting enzyme produces decreases in both preload and afterload.įollowing oral administration, fosinopril (the prodrug) is absorbed slowly. Although fosinopril sodium was antihypertensive in all races studied, black hypertensive patients (usually a low-renin hypertensive population) had a smaller average response to ACE inhibitor monotherapy than nonblack patients. While the mechanism through which fosinopril sodium lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, fosinopril sodium has an antihypertensive effect even in patients with lowrenin hypertension.

Whether increased levels of bradykinin, a potent vasodepressor peptide, play a role in the therapeutic effects of fosinopril sodium remains to be elucidated. Removal of angiotensin II negative feedback on renin secretion leads to increased plasma renin activity.ĪCE is identical to kininase, an enzyme that degrades bradykinin. Similar increases were observed among all patients treated with fosinopril, including those receiving concomitant diuretic therapy. In 647 hypertensive patients treated with fosinopril alone for an average of 29 weeks, mean increases in serum potassium of 0.1 mEq/L were observed.

The latter decrease may result in a small increase of serum potassium. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. In animals and humans, fosinopril sodium is hydrolyzed by esterases to the pharmacologically active form, fosinoprilat, a specific competitive inhibitor of angiotensin-converting enzyme (ACE).ĪCE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin l to the vasoconstrictor substance, angiotensin II.

For android instal 90 Minute Fever - Online Football (Soccer) Manager